The Proglucagon Enzyme Linked Immunosorbent Assay (ELISA) kit provides materials for the quantitative measurement of Proglucagon in human plasma and other biological fluids. No detectable cross-reactivity to Glucagon, GLP-1, GLP-2, Oxyntomodulin, GRPP, MPGF-1, MPGF-2, Insulin, C-Peptide, or Thyroglobulin.
96 well microtiter
Enquire about animal-specific cross-reactivity
HRP-based ELISA, colorimetric detection by dual wavelength absorbance at 450 nm and 630 nm as reference filter
6, 6.48 – 913 pg/mL
|Limit of Detection||
Proglucagon, a 158 amino acid polypeptide, is synthesized in the pancreatic alpha cells and the intestinal L-cells1. Its post-translational processing in the pancreas leads to GRPP, Glucagon, IP-1 and MPGF. While in the intestines, the post-translational process leads to Glicentin, Oxyntomodulin, GLP-1, IP-2 and GLP-2.2 Analogs and agonists of these proglucagon factors are used in the treatment and management of Type-1 and Type-2 diabetes and prevention of cardiovascular complications associated with diabetes.
- Jacques Philippe, Svetlana Mojsov, Daniel J. Drucker, Joel F. Habener., Proglucagon Processing in a Rat Islet Cell Line Resembles Phenotype of Intestine Rather than Pancreas, Endocrinology, Volume 119, Issue 6, 1 December 1986, Pages 2833–2839.
- Raffort, J., Lareyre, F., Massalou, D., Fénichel, P., Panaïa-Ferrari, P., & Chinetti, G. (2017). Insights on glicentin, a promising peptide of the proglucagon family. Biochemia medica, 27(2), 308–324.