Developing emerging biomarkers for reproductive health.
Most biomarkers start out with a specific application, however, as more researchers become involved, the range of applicable areas increases significantly. Initially, Anti-Mullerian Hormone (AMH) was used in determining neonatal gender in cases of ambiguous genitalia. Not long after, AMH became very popular in estimating ovarian reserve. In recent years, the level of interest in measuring AMH in PCOS patients has increased substantially. From the first publication about PCOS in December 2003, the number of AMH with PCOS and menopause studies has increased substantially and will likely exceed the number of ovarian reserve publications.
Ansh Labs’ current feature products include novel immunoassay test kits for reproductive function such as Anti-Müllerian hormone (AMH), Inhibin B, Inhibin A, Activin A, Follistatin, and other TGF-beta superfamily hormones involved in folliculogenesis [EduGraphic]. There are many ongoing studies of these hormones using our assays and rapidly growing interest in new diagnostic applications in gynecology and oncology. Our most recent additions to this assay family were Follistatin Like-3 and Activin B, along with GDF-9 and BMP-15 in development.
Following, we have put together a list of recommended readings that discuss in-depth the various assays and their role in the various disease states.
Jump to sections on Menopause, Premature Ovarian Failure (POF), Polycystic Ovary Syndrome, Cancers of the Reproductive System, Oncofertility, Male Infertility, Assisted Reproductive Technology, Disorders of Sex Development, Species-Specific Assays and Crossreactivity
* Unless otherwise stated in our catalog or other product documentation, these kits are intended for research use only and not for in vitro diagnostic purposes or therapeutic uses.
Ansh Labs’ research and discovery team is exploring the interplay of the various hormones that are involved in follicle recruitment, maturation, and dominant follicle selection. We specialize in the development of antibodies and immunoassays for TGF-ß superfamily hormones, biomarkers of cardiometabolic diseases, insulin-like growth factors, etc.
Click on the link below to view our latest educational graphic on Folliculogenesis. It was developed in collaboration with several key opinion leaders involved in human reproduction. We do plan to expand on this graphic so we welcome any recommendations you may have. Simply contact us on the Contact form and let us know your thoughts. The next iteration will include follicle size at each stage, estimated time frames for the follicle to progress, and estimated atresia amount at each stage. We can also provide the raw graphic files if you wish to translate or incorporate this into an educational piece.FIND OUT MORE