Activin-A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. The biological activities of Activin-A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, Follistatin. Human Activin-A is a 26 kDa disulfide-linked homodimer of two beta A chains, each containing 116 amino acid residues. Elevated levels of Activin-A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively.

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Activin A ELISA AL-110

Kalra B, Patel A, Kommareddy V, Ganapathy K, Mistry S, Budhavarapu V, Savjani G, Pasternack A, Ritvos O, Hyvonen M, Kumar A. Development of Novel Specific ELISAs for all Inhibins, Activins and their Binding Proteins FST and FSTL3. Poster presented at 98th Annual Endocrine Society Meeting; 2016 Apr 1-3; Boston, MA.

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Kim SY, Ebbert K, Cordeiro MH, Romero MM, Whelan KA, Suarez AA, Woodruff TK, Kurita T. Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors. Cancer Res. 2016 Jul 1;76(13):3851-61. PMID: 27197196

All Products Cited Activin A ELISA AL-110; Inhibin A ELISA AL-123; Inhibin B ELISA AL-107

Kristensen SG. Altered Levels of TGF-Beta Superfamily Growth Factors in Small Antral Follicle Fluids from Polycystic Ovaries. Poster session presented at the International Congress of Endocrinology, 2018 Dec 1-4, Cape Town South Africa. (597)

All Products Cited: GDF-9 ELISA AL-176; AMH ELISA AL-105; Activin A ELISA AL-110; Activin B ELISA AL-150; Activin AB ELISA Al-153; Follistatin ELISA AL-117

Kristensen SG, Kumar A, Kalra B, Pors SE, Bøtkjær JA, Mamsen LS, Colmorn LB, Fedder J, Ernst E, Owens LA, Hardy K, Franks S, Andersen CY. Quantitative Differences in TGF-β Family Members Measured in Small Antral Follicle Fluids From Women With or Without PCO. J Clin Endocrinol Metab. 2019 Dec 1;104(12):6371-6384. doi: 10.1210/jc.2019-01094. PMID: 31287539.

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Legro R, Dodson W, Estes S, Kunselman A, Coutifaris C, Dokras A. Effect of Weight Loss and Hormonal Suppression Alone and in Combination on Bioactive Gut and Ovarian Peptide Hormones in Women with Polycystic Ovary Syndrome Journal of the Endocrine Society, Volume 3, Issue Supplement_1, April-May 2019, MON-233, https://doi.org/10.1210/js.2019-MON-233

All Products Cited: Activin A ELISA AL-110; Follistatin ELISA AL-117; Inhibin A ELISA AL-123; Inhibin B ELISA AL-107; IGF-I ELISA AL-121; IGFBP-2 ELISA AL-140; Oxyntomodulin ELISA AL-139

Naseem H, Dreixler J, Mueller A, Tung A, Dhir R, Chibber R, Fazal A, Granger JP, Bakrania BA, deMartelly V, Rana S, Shahul S. Antepartum Aspirin Administration Reduces Activin A and Cardiac Global Longitudinal Strain in Preeclamptic Women. J Am Heart Assoc. 2020 Jun 16;9(12):e015997. doi: 10.1161/JAHA.119.015997. Epub 2020 Jun 4. PMID: 32495688; PMCID: PMC7429043.

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Panagiotou G, Papakonstantinou E, Vagionas A, Polyzos SA, Mantzoros CS. Serum Levels of Activins, Follistatins, and Growth Factors in Neoplasms of the Breast: A Case-Control Study. J Clin Endocrinol Metab. 2019 Feb 1;104(2):349-358. doi: 10.1210/jc.2018-01581. PubMed PMID: 30388235.

All Products Cited: Activin A ELISA AL-110; Activin B ELISA AL-150; Follistatin ELISA AL-117; Follistatin Like 3 ELISA AL-152; IGF-I ELISA AL-121; Total IGFBP-4 ELISA AL-126; Intact IGFBP-4 ELISA AL-128

Perakakis N, Chen J, Ghaly W, Vamvini MT, Mantzoros CS. Effects of oral and intravenous lipid administration on hormones affecting energy balance. Poster session presented at the Obesity Week Meeting; 2017 Oct 29‐Nov 2; Washington DC.

All Products Cited: Activin A ELISA AL‐110; Activin B ELISA AL‐150; Follistatin Like 3 ELISA AL‐152; Oxyntomodulin ELISA AL‐139

Perakakis N, Mougios V, Fatouros I, Siopi A, Draganidis D, Peradze N, Ghaly W, Mantzoros CS. Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and  Response to Exercise. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3890-3899. doi: 10.1210/jc.2018-01056. PubMed PMID: 30085147; PubMed Central PMCID: PMC6179167.

All Products Cited: Activin A ELISA AL-110; Activin B ELISA AL-150; Follistatin ELISA AL-117; Follistatin-like 3 ELISA AL-152

Perakakis N, Upadhyay J, Ghaly W, Chen J, Chrysafi P, Anastasilakis AD, Mantzoros CS. Regulation of the activins‐follistatins‐inhibins axis by energy status: Impact on reproductive function. Metabolism. 2018 May 9. pii: S0026‐0495(18)30120‐3.

All Products Cited: Activin A ELISA AL‐110; Activin B ELISA AL‐150; Follistatin Like 3 ELISA AL‐152; Inhibin B ELISA AL‐107; AMH ELISA AL‐105

Perakakis N, Upadhyay J, Ghaly W, Chen J, Mantzoros CS. Leptin‐dependent and leptin‐independent pathways linking energy sufficiency with reproduction. Poster session presented at the Obesity Week Meeting; 2017 Oct 29‐Nov 2; Washington DC.

All Products Cited: Activin A ELISA AL‐110; Activin B ELISA AL‐150; Follistatin Like 3 ELISA AL‐152; Inhibin B ELISA AL‐107; AMH ELISA AL‐105

Skory R, Xu Y, Shea L, Woodruff T. Engineering the ovarian cycle using in vitro follicle culture. Human Reproduction 2015 Mar 16 Epub ahead of print. PMID: 25784584

All Products Cited Activin A ELISA AL-110

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