Oxyntomodulin and Glicentin: Novel Biomarkers of Gastrointestinal and Metabolic Disorders

March 1, 2021

Oxyntomodulin and Glicentin: Novel Biomarkers of Gastrointestinal and Metabolic Disorders

(for research use only)



♦ Oxyntomodulin and Glicentin are secreted from enteroendocrine L-cells and  neuronal cells of brain along with glucagon-like peptide-1,  glucagon-like peptide-2 and peptide YY.

♦ Oxyntomodulin, which contains the glucagon sequence with a carboxyterminal extension, is a dual agonist of glucagon and GLP-1 receptors

♦ Glicentin, which contains the sequence of oxyntomodulin (and thus also of glucagon) with an N-terminal extension, and its receptor remains unknown

♦ Similar to GLP-1, oxyntomodulin and  glicentin has an insulinotropic action and exerts an incretin-like effect.

♦ OXM and glicentin inhibits food intake and stimulates energy expenditure in rodents and in human subjects.

♦ GLP-1 has a very short half-life of only 1 to 2 minutes, whereas oxyntomodulin has a circulating half-life of 12 minutes, and the predicted half-life of glicentin is around 30 to 35 minutes


Clinical Studies

Early-stage biomarker for nonalcoholic fatty liver disease (NAFLD)

♦ Circulating levels of GLP-1, GLP-2, glicentin, oxyntomodulin, glucagon, MPGF were measured in individuals with early stage NAFLD , biopsy proven NAFLD and nonalcoholic steatohepatitis [NASH]

♦ Patients in early stages of NAFLD demonstrated higher fasting MPGF and lower incremental increase of glicentin during oral glucose tolerance test than controls.

Best predictors of weight loss after gastric bypass surgery

♦ Postprandial responses of glicentin, oxyntomodulin, GLP-1, peptide YY (PYY), and ghrelin were measured before and 6 months after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG).

♦ Enhanced responses of oxyntomodulin and glicentin predicted a greater weight loss  and were associated with a larger decrease in energy density. No association between GLP-1 and weight loss


Ansh Labs’ Oxyntomodulin  ELISA (AL-139) and Ansh Labs’ Glicentin ELISA (AL-185)





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