PAPP-A monoclonal antibody, clone 1/41A, exhibits an IgG2a isotype and recognizes Heterotetrameric PAPP-A and Dimeric PAPP-A for human and mouse epitopes.
Catalog # AB-301-AP031-100UG
| Catalog Number(s) | AB-301-AP031-100UG |
|---|---|
| Size | 100 µg |
| Price | $1, 485 |
| Species Reactivity | Human, Mouse |
| Specificity | PAPP -A |
| Source | Murine |
| Clonality | Monoclonal Antibody |
| Isotype | IgG2a |
| Immunogen | Pregnancy Associated Plasma Protein – A (PAPP-A) |
| Application(s) | Neutralizing Ab, WB |
| Activity | Determined by direct ELISA |
| Product Appearance | Clear, Colorless solution |
| Purification | Purified from hybridoma culture supernatant using Protein G. |
| Composition | Phosphate Buffered Saline, 10mM, pH 7.4 (No Preservatives) |
| Regulatory Status | For Research Use Only. Not for use in diagnostic or therapeutic procedures. |
| Availability | Worldwide |
| Shipping Conditions | This product is shipped on dry ice. Upon receipt, store it immediately at the recommended temperature. |
The mouse-derived PAPP-A monoclonal antibody, clone 1/41A, exhibits an IgG2a isotype and recognizes Heterotetrameric PAPP-A and Dimeric PAPP-A. The monoclonal antibody was generated using a recombinant antigen as the immunogen and shows reactivity with human and mouse samples. The antibody is validated for use in Western blot and is a neutralizing antibody.
Mikkelsen JH, Resch ZT, Kalra B, Savjani G, Kumar A, Conover CA, Oxvig C. Indirect targeting of IGF receptor signaling in vivo by substrate-selective inhibition of PAPP-A proteolytic activity. Oncotarget. 2014; 5:1014–1025.
Heitzeneder S, Sotillo E, Shern JF, Sindiri S, Xu P, Jones R, Pollak M, Noer PR, Lorette J, Fazli L, Alag A, Meltzer P, Lau C, Conover CA, Oxvig C, Sorensen PH, Maris JM, Khan J, Mackall CL. Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion. J Natl Cancer Inst. 2019 Sep 1;111(9):970-982. doi: 10.1093/jnci/djy209.