Inhibin B is a dimeric hormone that is composed of alpha (α) and beta B (βB) subunits. The free alpha subunits usually do not have any physiological effect. Therefore, the bioactivity of the inhibins depends on the formation of a dimeric α-β structure, and only dimeric forms of inhibins are biologically active. Inhibins are protein hormones secreted by granulosa cells of the ovary in the female and sertoli cells of the testis in the male. They selectively suppress the secretion of pituitary follicle stimulating hormone (FSH) and also have local paracrine actions in the gonads. Inhibin B levels have been reported in sertoli cell function (potential marker for spermatogenesis and testicular function), ovarian reserve and granulosa cell tumors.

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Inhibin B ELISA AL-107

Chinya A, Ratan SK, Aggarwal SK, Garg A, Mishra TK. Association of levels of serum inhibin b and follicle stimulating hormone with testicular vascularity, volume, and echotexture in children with undescended testes.J Indian Assoc Pediatr Surg. 2017 Jan-Mar; 22(1): 3–8. PMC521713

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Istanbullu S, Lahlou N, Chevenne D, Léger J, Carel J, Martinerie L. Constitutional delay of puberty or hypogonadotropic hypogonadism: Diagnostic value of inhibin B and AMH measurements. Abstract presented at 55th European Society for Paediactric Endocrinology; 2016; Sep 10-12; Paris, France.

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Jain M, Kalsi AK, Srivastava A, Gupta YK, Halder A. High Serum Estradiol and Heavy Metals Responsible for Human Spermiation Defect-A Pilot Study. J Clin Diagn Res. 2016 Dec;10(12):RC09-RC13. PMID 28208955

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Kim SY, Ebbert K, Cordeiro MH, Romero MM, Whelan KA, Suarez AA, Woodruff TK, Kurita T. Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors. Cancer Res. 2016 Jul 1;76(13):3851-61. PMID 27197196

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Kumar A, Kalra B, Patel A, Shah S. Development of a Sensitive Inhibin B ELISA Optimized to Eliminate False Positive Results. Poster session presented at: American Association for Clinical Chemistry; 2013; Jul 30-Aug 1; Houston, TX.

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Lahlou N, Santullli P, Guibourdenche J, Beldjord C, Kottler, M, Chapron C, Gompel A. Unexpected Inhibin B, Insulin-like Peptide 3, and Testosterone Production by Mother Ovaries in a Pregnancy with Sustained High hCG Levels. A Clue to Hyperreactio Luteinalis? Poster session presented at: Endocrine Society’s 96th Annual Meeting; 2014; June 21-24; Chicago, IL.

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Liu DM, Torchen LC, Sung Y, Paparodis R, Legro RS, Grebe SK, Singh RJ, Taylor RL, Dunaif A Evidence for gonadotrophin secretory and steroidogenic abnormalities in brothers of women with polycystic ovary syndrome. Human Reproduction, Vol.29, No.12 pp. 2764–2772, 2014 Oct 21. PMID 25336708

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Perakakis N, Upadhyay J, Ghaly W, Chen J, Chrysafi P, Anastasilakis AD, Mantzoros CS. Regulation of the activins‐follistatins‐inhibins axis by energy status: Impact on reproductive function. Metabolism. 2018 May 9. pii: S0026‐0495(18)30120‐3.

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Ting A, Savjani G, Kalra B, Kumar A, Stouffer R, Zelinski M. Dynamics of Growth and Differentiation Factor‐9 and Inhibin B Production in Macaque Developing Follicles During 3‐Dimensional Culture. Poster Presentation at ASRM 2017 Oct 28‐Nov 1, San Antonio TX.

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Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK. A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle. Nat Commun. 2017 Mar 28;8:14584. PMID 28350383

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