Activin B ELISA

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The Activin B enzyme linked immunuosorbent assay (ELISA) kit provides materials for the quantitative measurement of Activin B in human serum, lithium heparin plasma and other biological fluids.

Regulatory Status

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Packaging

96 well microtiter

Detection

HRP-based ELISA, colorimetric detection by dual wavelength absorbance at 450 nm and 630 nm as reference filter

Dynamic Range

6, 12.7 – 1400 pg/mL

Limit of Detection

4.35 pg/mL

Sample Size

25 µL

Sample Type

Serum

Assay Time

3.5 hours

Species Reactivity

Bovine, Canine, Caprine, Equine, Fish, Human, Ovine, Rabbit

Shelf Life

24 months

Availability

Worldwide

Activins, like all members of the transforming growth factor-beta superfamily, are synthesized as large pro-hormones with N-terminal pro- and C-terminal mature domains. Studies have shown that the prodomains template the dimerization of pro-activin forms, that are subsequently processed to yield pro/mature fragments. The prodomains, although important for folding and extracellular localization, must be removed prior to activity. Activin forms retaining the prodomain are biologically inactive.

Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.

Activin B exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands.

Activin B ELISA AL-150

 

Kalra B, Patel A, Kommareddy V, Ganapathy K, Mistry S, Budhavarapu V, Savjani G, Pasternack A, Ritvos O, Hyvonen M, Kumar A Development of Novel Specific ELISAs for all Inhibins, Activins and their Binding Proteins FST and FSTL3. Poster presented at 98th Annual Endocrine Society Meeting; 2016 Apr 1-3; Boston, MA.

All Products Cited Activin A ELISA AL-110; Inhibin A ELISA AL-123; Inhibin B ELISA AL-107; Activin B ELISA AL-150; Activin AB ELISA AL-153; Follistatin ELISA AL-117; Follistatin Like 3 ELISA AL-152

 

Kristensen SG. Altered Levels of TGF-Beta Superfamily Growth Factors in Small Antral Follicle Fluids from Polycystic Ovaries. Poster session presented at the International Congress of Endocrinology, 2018 Dec 1-4, Cape Town South Africa. (597)

All Products Cited: GDF-9 ELISA AL-176; AMH ELISA AL-105; Activin A ELISA AL-110; Activin B ELISA AL-150; Activin AB ELISA Al-153; Follistatin ELISA AL-117

 

Panagiotou G, Papakonstantinou E, Vagionas A, Polyzos SA, Mantzoros CS. Serum Levels of Activins, Follistatins, and Growth Factors in Neoplasms of the Breast: A Case-Control Study. J Clin Endocrinol Metab. 2019 Feb 1;104(2):349-358. doi: 10.1210/jc.2018-01581. PubMed PMID: 30388235.

All Products Cited: Activin A ELISA AL-110; Activin B ELISA AL-150; Follistatin ELISA AL-117; Follistatin Like 3 ELISA AL-152; IGF-I ELISA AL-121; Total IGFBP-4 ELISA AL-126; Intact IGFBP-4 ELISA AL-128

 

Perakakis N, Chen J, Ghaly W, Vamvini MT, Mantzoros CS. Effects of oral and intravenous lipid administration on hormones affecting energy balance. Poster session presented at the Obesity Week Meeting; 2017 Oct 29‐Nov 2; Washington DC.

All Products Cited: Activin A ELISA AL‐110; Activin B ELISA AL‐150; Follistatin Like 3 ELISA AL‐152; Oxyntomodulin ELISA AL‐139

 

Perakakis N, Mougios V, Fatouros I, Siopi A, Draganidis D, Peradze N, Ghaly W, Mantzoros CS. Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise. J Clin Endocrinol Metab. 2018 Oct 1;103(10):3890-3899. doi: 10.1210/jc.2018-01056. PubMed PMID: 30085147; PubMed Central PMCID: PMC6179167.

All Products Cited: Activin A ELISA AL-110; Activin B ELISA AL-150; Follistatin ELISA AL-117; Follistatin-like 3 ELISA AL-152

 

Perakakis N, Upadhyay J, Ghaly W, Chen J, Chrysafi P, Anastasilakis AD, Mantzoros CS. Regulation of the activins‐follistatins‐inhibins axis by energy status: Impact on reproductive function. Metabolism. 2018 May 9. pii: S0026‐0495(18)30120‐3.

All Products Cited: Activin A ELISA AL‐110; Activin B ELISA AL‐150; Follistatin Like 3 ELISA AL‐152; Inhibin B ELISA AL‐107; AMH ELISA AL‐105

 

Perakakis N, Upadhyay J, Ghaly W, Chen J, Mantzoros CS. Leptin‐dependent and leptin‐independent pathways linking energy sufficiency with reproduction. Poster session presented at the Obesity Week Meeting; 2017 Oct 29‐Nov 2; Washington DC.

All Products Cited: Activin A ELISA AL‐110; Activin B ELISA AL‐150; Follistatin Like 3 ELISA AL‐152; Inhibin B ELISA AL‐107; AMH ELISA AL‐105

 

Richani D, Constance K, Lien S, Agapiou D, Stocker WA, Hedger MP, Ledger WL, Thompson JG, Robertson DM, Mottershead DG, Walton KL, Harrison CA, Gilchrist RB. Cumulin and FSH Cooperate to Regulate Inhibin B and Activin B Production by Human Granulosa-Lutein Cells In Vitro. Endocrinology. 2019 Apr 1;160(4):853-862. doi: 10.1210/en.2018-01026. PubMed PMID: 30753406.

All Products Cited: Activin B ELISA AL-150